HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazinecarboxaldehyde → HCID 22599545, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazinecarboxaldehyde | HCID 12229 | — |
| Reactant | HCID 22599567 | HCID 22599567 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 22599545 | HCID 22599545 | — |
Reaction Steps
A mixture of 1,3-dihydro-5-(ethylthio)-1-methyl-2H-1,4-benzodiazepin-2-one (1 eq.) and formic hydrazide (5.8 eq. Aldrich) in n-butanol (0.1 M in benzodiazepine) was stirred at reflux under N2 for 24 hours. An additional 1.67 eq. of formic hydrazide was added and refluxing continued an additional 16 hours. The yellow solution was evaporated in vacuo and the residue was purified via flash chromatography eluting with a gradient from 98:2 to 96:4 CH2Cl2/MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06552013B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-14dcdb4915704c58b55350937feda0c5 |
| Source note | uspto-grants-2003_04 |