(2S)-2-(((tert-butoxy)carbonyl)amino)pentanoic acid → HCID 131723864, compound

HRID 1267194Notes

Reaction equation

HRID 1267194 reaction equation
[NH2:1][CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]([CH3:15])[C:3]1=[O:16].[C:17]([NH:24][C@H:25]([C:29](O)=[O:30])[CH2:26][CH2:27][CH3:28])([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]>>[C:20]([O:19][C:17]([NH:24][C@H:25]([C:29]([C:2]1([NH2:1])[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]([CH3:15])[C:3]1=[O:16])=[O:30])[CH2:26][CH2:27][CH3:28])=[O:18])([CH3:22])([CH3:23])[CH3:21]

Participants

3

Reactant 2

HCID 2733748(2S)-2-(((tert-butoxy)carbonyl)amino)pentanoic acidHCID 22312383HCID 22312383, compound

Product 1

HCID 131723864HCID 131723864, compound

Procedure

Following General Procedure D using the product from Example 4-R, Step C and Boc-L-norvaline (BACHEM) the title intermediate was prepared. HPLC purification eluting with EtOAc/Hexanes (60:40) afforded the title intermediate as a white solid.

Workup

  1. customwas prepared
  2. customHPLC purification
  3. washeluting with EtOAc/Hexanes (60:40)

Sources & evidence

ORD record
ord-b779b39d3db34f579513d15b6f0f2a87
Source dataset
uspto-grants-2003_04
Patent number
US06552013B1

Reaction notes

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