反应详情

3-Benzoyl-5-iodo-1-{3-[(1S,5R)-1-(4-trifluoromethyl-phenyl)-3-aza-bicyclo[3.1.0]hex-3-yl]-propyl}-1H-pyrimidine-2,4-dione (Prep 39, 840 mg, 1.38 mmol) was dissolved in 10% NH3 in MeOH solution (5 mL). The mixture was stirred at room temperature for 1 hour, the solvent was then evaporated under vacuum and the crude purified by flash chromatography with DCM-MeOH—NH4OH (98-2-1) to give the title compound as a white solid (515 mg, 74% yield).

1. customthe solvent was then evaporated under vacuum
2. customthe crude purified by flash chromatography with DCM-MeOH—NH4OH (98-2-1)