Thionyl Chloride → 3,4-Dichloro-5-isothiazolecarbonyl chloride

HRID 1267212Notes

Reaction equation

HRID 1267212 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8]([OH:10])=O)[S:4][N:3]=1.S(Cl)([Cl:13])=O>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8]([Cl:13])=[O:10])[S:4][N:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 498373,4-Dichloro-5-isothiazolecarboxylic acid

Product 1

HCID 109768863,4-Dichloro-5-isothiazolecarbonyl chloride

Procedure

After thionyl chloride (10 ml) had been added to 3,4-dichloro-5-isothiazole-carboxylic acid (0.99 g), the mixture was refluxed by heating for 2 hours. The excess of thionylchloride was then distilled off under reduced pressure, and 3,4-dichloro-5-isothiazolecarboxylic acid chloride was obtained.

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureby heating for 2 hours
  3. distillationThe excess of thionylchloride was then distilled off under reduced pressure

Sources & evidence

ORD record
ord-ba38ff66eb8a44dbaedffd94a7384d0a
Source dataset
uspto-grants-2003_04
Patent number
US06552056B2

Reaction notes

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