1-Methylhomopiperazine → HCID 22558208, compound

HRID 1267283Notes

Reaction equation

HRID 1267283 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:13][N:14]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8]([N:17]3[CH2:18][CH2:19][CH2:20][N:14]([CH3:13])[CH2:15][CH2:16]3)=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 2

HCID 2283491-MethylhomopiperazineHCID 178424102HCID 178424102, compound

Product 1

HCID 22558208HCID 22558208, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5,7-Dimethyl-2-mercaptobenzoxazole (220 mg) was dissolved in chloroform (20 ml), N-methylhomopiperazine (0.76 ml) was added dropwise to the solution and then the mixture was stirred with heating for 2 days. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the title compound 5,7-dimethyl-2-(4-methyl-1-homopiperazinyl)benzoxazole (110 mg).

Workup

  1. temperaturewith heating for 2 days
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1)

Sources & evidence

ORD record
ord-ef9a821aa5f94de585c8a019aaaf5bce
Source dataset
uspto-grants-2003_04
Patent number
US06552057B2

Reaction notes

Loading…