Ethylene Glycol → 2-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one-7-ethylene ketal

Participants

Reaction Steps

A solution of 5.5 g. of 2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one (Example 88), 25 ml. of ethylene glycol, and 0.1 g. of P-toluenesulfonic acid in 200 ml. of toluene is reflucted for 40 minutes using a Dean-Stark trap. The solution is poured into saturated sodium bicarbonate. The mixture is extracted with benzene. The organic solution is washed three times with water and dried over magnesium sulfate. The solvent is removed to give 6.0 g. of the title compound.

Provenance & Evidence