Hydrochloric Acid → HCID 12961138, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-nitro-4-benzyloxyphenylglyoxylic acid (30 g.), conc. hydrochloric acid (90 ml.) and acetic acid (120 ml.) was stirred for 3 hours at 100° C. To the reaction mixture was added under cooling ice-water (600 ml.) and the mixture was extracted with ethyl acetate. The extract was washed with ice-water, dried over magnesium sulfate and concentrated to dryness under reduced pressure. The residue was recrystallized from a mixture of benzene: ether: petroleum ether (2:1:4). The crystals were collected by filtration, washed with benzene and dried under reduced pressure to give 3-nitro-4-hydroxyphenylglyoxylic acid (19.0 g.), mp 139° to 140.5° C.

Provenance & Evidence