HCID 10305403, compound → HCID 23680341, compound

HRID 1267497Notes

Reaction equation

[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH:29]([CH2:33][CH2:34][C:35]([F:47])([F:46])[C:36]([F:45])([F:44])[C:37]([F:43])([F:42])[C:38]([F:41])([F:40])[F:39])[C:30]([OH:32])=[O:31])[C:7]([C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)([CH3:12])[CH2:8][O:9]2)=[CH:4][CH:3]=1.C[O-].[Na+:50]>>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH:29]([CH2:33][CH2:34][C:35]([F:47])([F:46])[C:36]([F:44])([F:45])[C:37]([F:42])([F:43])[C:38]([F:39])([F:40])[F:41])[C:30]([O-:32])=[O:31])[C:7]([C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)([CH3:12])[CH2:8][O:9]2)=[CH:4][CH:3]=1.[Na+:50]

Participants

Reactant 2

HCID 10305403HCID 10305403, compound

HCID 10942334Sodium Methoxide

Product 1

HCID 23680341HCID 23680341, compound

Procedure

Starting with the 11-[(3RS,4RS)-7-hydroxy-3-(4-hydroxyphenyl)-3-methylchroman-4-yl]-2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)undecanoic acid prepared in Example 14 and sodium methoxide (1.0 mol/l in methanol), a procedure analogous to that as shown in Example 27 was repeated to give sodium 11-[(3RS,4RS)-7-hydroxy-3-(4-hydroxyphenyl)-3-methylchroman-4-yl]-2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)undecanoate.

Sources & evidence

ORD record: ord-a7e04c74e9dd42c6a697c527c078575b
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06552069B1

Reaction notes

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