Methylamine → HCID 9926596, compound

Participants

Reaction Steps

To 10 mL of 40% aqueous methylamine was added 0.3 g (1.0 mmol) of 2-(4-(2-fluorophenyl)phenyl)propanesulfonyl chloride above in 3 mL of tetrahydrofuran and the mixture stirred at room temperature for 16 hours. The reaction mixture was extracted three times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate/hexanes) of the residue afforded 0.1 g (42%) of the title compound.

Provenance & Evidence