Ammonium Chloride → HCID 18546514, compound

Participants

Reaction Steps

A solution of 14.57 g (81 mmol) N-(2-methoxybenzylidene)isopropylamin in 50 ml THF was added dropwise to a Grignard reagent prepared from 18.01 g (90 mmol) 2-bromo-5-fluorotoluene and 2.19 g (90 mmol) magnesium turnings in 50 ml THF. The mixture was heated at reflux for 12 hrs. The mixture was poured with vigorous stirring into an aqueous solution of NH4Cl (25 %) and stirred for 1 h. Extraction with CH2Cl2, drying (Na2SO4) and evaporation gave 20.83 g (98%) (4′-fluoro-2′-methyl-biphenyl-2-ylmethylene)-isopropyl-amine as a pale yellow oil.

Provenance & Evidence