HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → HCID 18546875, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | HCID 18546878 | HCID 18546878 | — |
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Solvent | Water ethylacetate | HCID 22728543 | — |
| Product | HCID 18546875 | HCID 18546875 | 88% |
Reaction Steps
1 mmol of 6-(3-methoxybenzylamino)-2-chloro-9-isopropylpurine was brominated with 1.1 mmol of bromine as described in Example 1. The crude 2,8-dihalogeno derivative prepared was alkalinized with NH3/MeOH and extacted between water-EtOAc. The product crystallizes after partial evaporation of ethylacetate. M.p.123-125° C., yield 88%. MS-ESI(+)m/z 409.5, 411.4, 413.3 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06552192B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-7690d18fccf64c93b6ade4a71d5d4e96 |
| Source note | uspto-grants-2003_04 |