反应详情

1-cyclopropyl-5-amino-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinoline-carboxylic acid, 1.05 g of t-butyl 8-(methoxyimino)-2,6-diazaspiro[3,4]octane-2-carboxylate and 4 g of AmberliteR IRA-420 were added to 20 ml of acetonitrile and thereto 2 ml of triethylamine was added by dropping. The mixture was refluxed for 5 days and then 2 ml of dimethylformamide was added thereto. The resulting mixture was stirred for 1 hour and thus precipitated solid was filtered off. The filtrate was concentrated under the reduced pressure and then to the resulting residue 10 ml of acetonitrile was added and stirred for 1 hour. The precipitated solid was filtered and dried to give 420 mg of the titled compound (yield: 30.9%).

1. temperatureThe mixture was refluxed for 5 days
2. filtrationthus precipitated solid was filtered off
3. concentrationThe filtrate was concentrated under the reduced pressure
4. additionto the resulting residue 10 ml of acetonitrile was added
5. stirringstirred for 1 hour
6. filtrationThe precipitated solid was filtered
7. customdried