反应详情

7-[2-(t-butoxycarbonyl)-8-(methoxyimino)-2,6-diazaspiro[3,4]oct-6-yl]-1-cyclo propyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolincarboxylic acid was dissolved in 5 ml of dichloromethane and thereto 1 ml of trifluoroacetic acid was added by dropping. The resulting mixture was stirred at room temperature for 18 hours, and thereto 10 ml of ethylether was added. The resulting precipitate was filtered and dried. Thus obtained solid was dissolved in 2 ml of diluted NaOH and neutralized with diluted hydrochloric acid, and the resulting precipitate was filtered and dried. The solid thus obtained was added to 2 ml of 1N-methanesulfonic acid in ethanol and stirred at room temperature for 3 hours. The precipitate was filtered and dried to give 35 mg of the titled compound (yield: 28.5%).

1. filtrationThe resulting precipitate was filtered
2. customdried
3. dissolutionThus obtained solid was dissolved in 2 ml of diluted NaOH and neutralized with diluted hydrochloric acid
4. filtrationthe resulting precipitate was filtered
5. customdried
6. customThe solid thus obtained
7. stirringstirred at room temperature for 3 hours
8. filtrationThe precipitate was filtered
9. customdried