Hexahydro-1,4-diazepine → HCID 18546827, compound

HRID 1267629Notes

Reaction equation

HRID 1267629 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)[CH:4]=1.[NH:21]1[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:20][O:19][C:11]1[CH:10]=[C:9]([C:5]2[CH:4]=[C:3]([CH2:2][N:21]3[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[CH:8]=[CH:7][N:6]=2)[CH:14]=[C:13]([O:15][CH3:16])[C:12]=1[O:17][CH3:18]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine

Product 1

HCID 18546827HCID 18546827, compound

Procedure

4-Chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (588 mg) and homopiperazine (801 mg) were treated in the same manner as in Preparation Example 4 to obtain the title compound.

Sources & evidence

ORD record
ord-63348111a8f84f3a949628895df13532
Source dataset
uspto-grants-2003_04
Patent number
US06552188B2

Reaction notes

Loading…