(Naphthalen-2-yl)boronic acid → Ethyl 2-(2-naphthyl)isonicotinate

HRID 1267643Notes

Reaction equation

HRID 1267643 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1B(O)O.Cl[C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][N:25]=1)[C:18]([O:20][CH2:21][CH3:22])=[O:19]>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][N:25]=1)[C:18]([O:20][CH2:21][CH3:22])=[O:19]

Participants

3

Reactant 2

HCID 2734375(Naphthalen-2-yl)boronic acidHCID 2762942Ethyl 2-chloroisonicotinate

Product 1

HCID 18546788Ethyl 2-(2-naphthyl)isonicotinate

Procedure

2-Naphthylboronic acid (3.50 g) and ethyl 2-chloroisonicotinate (3.77 g) were reacted in the same manner as in Preparation Example 1 to obtain the title compound.

Sources & evidence

ORD record
ord-bdab134b5c2d4486996c7c6b93a816b4
Source dataset
uspto-grants-2003_04
Patent number
US06552188B2

Reaction notes

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