Water → HCID 18546789, compound

Participants

Reaction Conditions

Reaction Steps

4-Methyl-6-(3,4,5-trimethoxyphenyl)pyrimidine (920 mg) was dissolved in dioxane (100 mL), and to the solution selenium dioxide (784 mg) was added, and the mixture was stirred overnight at 105° C. Water was added to the reaction mixture to conduct extraction with ethyl acetate, and the resultant organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:1) to obtain the title compound.

Provenance & Evidence