Methanol → HCID 178487584, compound

HRID 1267647Notes

Reaction equation

HRID 1267647 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[N:18]=[CH:17][N:16]=[C:15](C=O)[CH:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[BH4-].[Na+].C[OH:24]>>[OH:24][C:15]1[CH:14]=[C:13]([C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=2)[N:18]=[CH:17][N:16]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 18546789HCID 18546789, compound

Product 1

HCID 178487584HCID 178487584, compound

Procedure

6-(3,4,5-Trimethoxyphenyl)pyrimidine-4-carboaldehyde (364 mg) was dissolved in methanol (50 mL), and to the solution sodium borohydride (25 mg) was added under ice cooling, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (chloroform:methanol=50:1) to obtain the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by column chromatography on silica gel (chloroform:methanol=50:1)

Sources & evidence

ORD record
ord-3efb6a09dbca4a2f83747829fe362a82
Source dataset
uspto-grants-2003_04
Patent number
US06552188B2

Reaction notes

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