Acetic Acid → HCID 54399126, compound

HRID 126765Notes

Reaction equation

HRID 126765 reaction equation
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].C(O)(=O)C.[CH3:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[C:22](=[O:23])[NH:21][CH:20](SC)[NH:19][C:18]2=[O:26])=[CH:13][CH:12]=1>O>[CH3:10][C:11]1[CH:12]=[CH:13][C:14]([N:17]2[C:18](=[O:26])[NH:19][CH:20]([NH:5][CH2:1][CH:2]([CH3:4])[CH3:3])[NH:21][C:22]2=[O:23])=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6558IsobutylamineHCID 538772003-(4-Methylphenyl)-6-methylthiotetrahydro-1,3,5-triazine-2,4-dione

Product 1

HCID 54399126HCID 54399126, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Isobutylamine (1.60 g.) was added to acetic acid (1.20 g.) at 20°-25° C. during 15 minutes. 3-(4-Methylphenyl)-6-methylthiotetrahydro-1,3,5-triazine-2,4-dione (4.98 g.) was then added, and the whole mixture stirred at 120°-125° C. for 5 hours and then cooled. Water (50 ml.) was added and the mixture stirred thoroughly. The solid produced was collected by filtration, washed with water and dried to give 3-(4-methylphenyl)-6-isobutylaminotetrahydro-1,3,5-triazine-2,4-dione (4.90 g., 89%), m.p. 297°-301° C.

Workup

  1. temperaturecooled
  2. stirringthe mixture stirred thoroughly
  3. customThe solid produced
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-cf53970221dc43ae8855f5dac0e41146
Source dataset
uspto-grants-1981_03
Patent number
US04254122

Reaction notes

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