Phenylacetyl chloride → Hydrochloric Acid

Participants

Reaction Steps

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]-piperazine (103 mg) was dissolved in dichloromethane (0.9 mL), and to the solution phenylacetyl chloride (60 mg) was added, and the mixture was stirred for 1 hour under ice cooling. A saturated aqueous solution of sodium hydrogencarbonate was added to the reaction mixture to conduct extraction with chloroform. The resultant organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (chloroform:methanol=50:1) to obtain the title compound in the form of a hydrochloride.

Provenance & Evidence