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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1267665Generated: October 31, 2026

2-Naphthoyl chloride → N-(2-naphthoyl)-N'-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperazine

https://huagongshe.com/reaction/1267665

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Naphthoyl chlorideHCID 75246—
Reactant1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]-methyl]piperazineHCID 12021155—
ProductN-(2-naphthoyl)-N'-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperazineHCID 18546824—

Reaction Steps

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]-piperazine (103 mg) and 2-naphthoyl chloride (57 mg) were reacted in the same manner as in Example 46 to obtain the title compound as a free base.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06552188B2
Source datasetuspto-grants-2003_04
ORD IDord-cb7a06cb554c4474a4112f630a3c9b81
Source noteuspto-grants-2003_04