HRID1267669

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(-c2cc(CN3CCNCC3)ccn2)cc(OC)c1OC

HCID12021155

未命名化合物

HCID12043485

2-(3,4,5-trimethoxyphenyl)isonicotinic acid

C15H15NO5

PRODUCTS

生成物

结构：COc1cc(-c2cc(CN3CCN(C(=O)c4ccnc(-c5cc(OC)c(OC)c(OC)c5)c4)CC3)ccn2)cc(OC)c1OC

HCID18546840

未命名化合物

PROCEDURE

实验过程

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]-piperazine (160 mg) and 2-(3,4,5-trimethoxyphenyl)-isonicotinic acid (113 mg) were reacted in the same manner as in Example 56 to obtain the title compound as a free base.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-58e44b84e26144da8b8e14a6789e0bde
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06552188B2
来源说明: uspto-grants-2003_04

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH3:26][O:27][C:28]1[CH:29]=[C:30]([C:38]2[CH:39]=[C:40]([CH:44]=[CH:45][N:46]=2)[C:41](O)=[O:42])[CH:31]=[C:32]([O:36][CH3:37])[C:33]=1[O:34][CH3:35]>>[CH3:26][O:27][C:28]1[CH:29]=[C:30]([C:38]2[CH:39]=[C:40]([CH:44]=[CH:45][N:46]=2)[C:41]([N:23]2[CH2:24][CH2:25][N:20]([CH2:19][C:17]3[CH:16]=[CH:15][N:14]=[C:13]([C:5]4[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=4)[CH:18]=3)[CH2:21][CH2:22]2)=[O:42])[CH:31]=[C:32]([O:36][CH3:37])[C:33]=1[O:34][CH3:35]