反应详情

A solution of 9 g of 2-amino-3-chloro-quinoxaline, 12 g of ethyl bromopyruvate and 180 ml of dimethoxyethane was stirred overnight and was then filtered to obtain 5.33 g of 1-carbethoxycarbonylmethyl-2-amino-3-chloro-quinoxalinium bromide as a pale yellow crystalline solid. The filtrate was stirred in the refrigerator for 2 days to obtain two additional yields of 1.20 g and 3.62 g of the product for a total yield of 10.22 g.

1. filtrationwas then filtered