2-Amino-5-methylpyridine → HCID 69539502, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (R)-N-(2,3-dichloro-4-chlorosulphonylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide (200 mg, 0.5 mmol) (Method 1) and 2-amino-5-methylpyridine (81 mg, 0.80 mmol) in pyridine (5 ml) was stirred at 80° C. overnight. The mixture was cooled to ambient temperature, poured onto water (50 ml) and extracted with EtOAc (2×25 ml). The organic layer was separated, washed with 1 M aqueous hydrochloric acid, saturated sodium hydrogen carbonate solution, brine, dried and evaporated to give the title compound as a solid (40 mg, 0.08 mmol); NMR: 1.6 (s, 3H), 2.1 (s, 3H), 7.1 (d, 1H), 7.6 (d, 1H), 7.75 (s, 1H), 8.1 (s, 2H); m/z 470.

Provenance & Evidence