Acetone → Sodium imidazo-[1,2-a]-quinoxaline-2-carboxylate

HRID 126776Notes

Reaction equation

HRID 126776 reaction equation
[OH-].[Na+:2].[CH:3]1[N:7]2[C:8]3[C:13]([N:14]=[CH:15][C:6]2=[N:5][C:4]=1[C:16]([OH:18])=[O:17])=[CH:12][CH:11]=[CH:10][CH:9]=3.CC(C)=O>O>[CH:3]1[N:7]2[C:8]3[C:13]([N:14]=[CH:15][C:6]2=[N:5][C:4]=1[C:16]([O-:18])=[O:17])=[CH:12][CH:11]=[CH:10][CH:9]=3.[Na+:2]

Participants

5

Reactant 3

HCID 180AcetoneHCID 14798Sodium HydroxideHCID 71146Dazoquinast

Product 1

HCID 23698892Sodium imidazo-[1,2-a]-quinoxaline-2-carboxylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Aqueous 2 N sodium hydroxide solution was added dropwise to a stirred suspension of 2 g of imidazo-[1,2-a]-quinoxaline-2-carboxylic acid in 20 ml of water until dissolution occured at a pH of 9-10. Acetone was added to the mixture to cause precipitation and the mixture was filtered to obtain 1.8 g of sodium imidazo-[1,2-a]-quinoxaline-2-carboxylate melting at >300° C.

Workup

  1. customprecipitation
  2. filtrationthe mixture was filtered

Sources & evidence

ORD record
ord-6010b13c11914ebc81748009d6ff8a06
Source dataset
uspto-grants-1981_03
Patent number
US04254123

Reaction notes

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