HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → 11-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)thiochroman-4-yl]-2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)undecanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | 1,1,1,2,2,3,3,4,4-Nonafluoro-6-iodohexane | HCID 74887 | — |
| Reactant | 8-Bromooct-1-ene | HCID 75907 | — |
| Reactant | 10-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)thiochroman-4-yl]-2-(7,7,8,8,8-pentafluoro-octyl)decanoic acid | HCID 18546277 | — |
| Reactant | Ethyl 2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-9-decenoate | HCID 22718077 | — |
| Product | 11-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)thiochroman-4-yl]-2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)undecanoic acid | HCID 10283672 | — |
Reaction Steps
Starting with the ethyl 2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-9-decenoate prepared from diethyl malonate, 8-bromo-1-octene and 1-iodo-3,3,4,4,5,5,6,6,6-nonafluorohexane as in Example 5 and the allyl compound prepared in Example 13, the same procedure as shown in Example 13 was repeated to give 11-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)thiochroman-4-yl]-2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)undecanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06552068B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-9c77b10156674f48a9f9bcf12ac66614 |
| Source note | uspto-grants-2003_04 |