HRID1267786

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCC1(c2ccc(O)cc2)CSc2cc(O)ccc2C1CCCCCCCCC(CCCC(F)(F)C(F)(F)F)C(=O)O

HCID10211406

未命名化合物

结构：C=CCCCCCC(CCCCC(F)(F)C(F)(F)F)C(=O)OCC

HCID18546257

未命名化合物

PRODUCTS

生成物

结构：CCCC1(c2ccc(O)cc2)CSc2cc(O)ccc2C1CCCCCCCCC(CCCCC(F)(F)C(F)(F)F)C(=O)O

HCID10168368

未命名化合物

PROCEDURE

实验过程

Starting with the allyl compound prepared in Example 29 and ethyl 2-(5,5,6,6,6-pentafluorohexyl)-8-nonenoate prepared separately, the same procedure as shown in Example 13 was repeated to give 10-[(3RS,4RS)-7-hydroxy-3-(4-hydroxyphenyl)-3-propylthiochroman-4-yl]-2-(5,5,6,6,6-pentafluorohexyl)decanoic acid.

WORKUP

后处理

customprepared separately

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ae59b85212b542d38f13af00c0b71237
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06552068B1
来源说明: uspto-grants-2003_04

反应 SMILES

[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH:30]([CH2:34][CH2:35]CC(F)(F)C(F)(F)F)[C:31]([OH:33])=[O:32])[C:7]([C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)([CH2:12][CH2:13][CH3:14])[CH2:8][S:9]2)=[CH:4][CH:3]=1.[F:44][C:45]([F:67])([C:63]([F:66])([F:65])[F:64])[CH2:46][CH2:47]CCC(CCCCCC=C)C(OCC)=O>>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH:30]([CH2:34][CH2:35][CH2:47][CH2:46][C:45]([F:67])([F:44])[C:63]([F:66])([F:65])[F:64])[C:31]([OH:33])=[O:32])[C:7]([C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)([CH2:12][CH2:13][CH3:14])[CH2:8][S:9]2)=[CH:4][CH:3]=1