Boc-DAla-Phe-Met-OCH3 → H-DAla-Phe-Met-OCH3.HCl

HRID 126785Notes

Reaction equation

HRID 126785 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:4]([NH:6][C@H:7]([C:15]([NH:17][C@H:18]([C:23]([O:25][CH3:26])=[O:24])[CH2:19][CH2:20][S:21][CH3:22])=[O:16])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])[CH3:3].[ClH:34].C1(OC)C=CC=CC=1.CCOC(C)=O>>[NH2:1][C@@H:2]([C:4]([NH:6][C@H:7]([C:15]([NH:17][C@H:18]([C:23]([O:25][CH3:26])=[O:24])[CH2:19][CH2:20][S:21][CH3:22])=[O:16])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])[CH3:3].[ClH:34]

Participants

3

Reactant 2

HCID 12888621Boc-DAla-Phe-Met-OCH3HCID 131712093HCl anisole EtOAc

Product 1

HCID 131712091H-DAla-Phe-Met-OCH3.HCl

Procedure

Boc-DAla-Phe-Met-OCH3 (9.4 g) was treated with HCl/anisole/EtOAc as described in Step B to give H-DAla-Phe-Met-OCH3.HCl which was used without further purification.

Sources & evidence

ORD record
ord-a8f24889cb5948dba12a1b274adc7a25
Source dataset
uspto-grants-1981_03
Patent number
US04254024

Reaction notes

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