HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Glutamine → 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Glutamine | HCID 5961 | — |
| Reactant | 2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic acid | HCID 186109 | — |
| Product | 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione | HCID 91585 | — |
Reaction Steps
In a further method, a dialdehyde is allowed to react with glutamine and the resulting 2-(1-oxoisoindolin-2-yl)glutaric acid then cyclized to yield a 1-oxo-2-(2,6-dioxopiperidin-3-yl)-isoindoline of Formula I:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06555554B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-fe2f087eb54343649f913b6c3aec4a4e |
| Source note | uspto-grants-2003_04 |