HCID 70009058, compound → HCID 70009050, compound

Participants

Reaction Steps

(1R*,2R*,5S*,6R*)-2-benzylamino-8-benzyl-1-phenyl-6-phenylsulphonyl-8-azabicyclo[3.2.1]octane (Description 4; 1.73 g, 3.3 mmol) was dissolved in a mixture of methanol (30 mL) and acetic acid (20 mL), then treated with 10% palladium on charcoal (500 mg). The suspension was hydrogenated at 50 psi hydrogen for 16 hours, then filtered and concentrated. The residue was basified with saturated sodium bicarbonate solution (100 mL) and extracted with dichloromethane (2×100 mL). The extracts were dried (MgSO4) and concentrated, and the residue purified by silica chromatography to give the title compound as a gum (1.10 g, 3.2 mmol).

Provenance & Evidence