Sodium Phosphate, Dibasic → HCID 69654642, compound

Participants

Reaction Steps

(1R*,2R*,5S*,6R*)-2-amino-1-phenyl-6-phenylsulphonyl-8-azabicyclo[3.2.1]octane (Description 5; 1.0 g, 2.9 mmol) in methanol (20 mL) was treated with disodium hydrogen phosphate (1.65 g, 11.6 mmol) and 10% sodium amalgam (2.67 g), and the mixture stirred for 40 minutes. Saturated sodium bicarbonate solution (100 mL) was then added and the suspension extracted with dichloromethane (2×100 mL). The extracts were dried (MgSO4) and concentrated, and the residue purified by silica chromatography to give the title compound as a gum (315 mg, 1.6 mmol).

Provenance & Evidence