Potassium Iodide → HCID 54034060, compound

Participants

Reaction Conditions

Reaction Steps

Potassium iodide (10 mg), 3,4-difluoroaniline (0.4 ml), N,N-diisopropyl ethylamine (0.9 ml) and 4-[4-chloro-3-(2-chloro-acetylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (500 mg) were combined in N,N-dimethylformamide (10 ml) and heated at 90° C. for 24 hr. After cooling to room temperature, the reaction was poured into ethyl acetate/water. The organic layer was separated, washed with water (×3) and brine, dried (MgSO4) and concentrated. Purification of the residue by silica gel chromatography (eluting ethyl acetate/iso-hexane (1:2 to 1:1) gave the subtitle product (360 mg).

Provenance & Evidence