反应详情

Prepared according to the procedure of Example 11c) using (3,4-difluoro-phenyl)-[(5-hydroxymethyl-2-methyl-phenylcarbamoyl)-methyl]-carbamic acid tert-butyl ester and 1-(2-pyrimidyl)piperazine dihydrochloride to give the title compound as a 10 mM solution in dimethyl sulfoxide. An aliquot (30 mL) of this solution was diluted with dimethyl sulfoxide/water (220 mL of a 1:1 mixture) was analysed by HPLC on a 20 mm×3.9 mm Waters Symmetry C8 column, eluting with 30%-95% acetonitrile/ammonium acetate.

1. customPrepared