Potassium Carbonate → HCID 12043041, compound

Participants

Reaction Steps

A benzene (10 ml) solution containing 600 mg (2.3 mmol) of 3-benzyloxybenzoic acid and 1.5 ml of thionyl chloride was heated under reflux for 2 hours and then the solvent was evaporated. A dioxane (10 ml) solution of the resulting residue was added dropwise to a water-dioxane 1:1 (10 ml) solution containing 248 mg (1.44 mmol) of 2-amino-benzenesulfonamide and 726 mg (5.2 mmol) of potassium carbonate, and the mixture was stirred at room temperature for 3 hours. After completion of the reaction, dioxane was evaporated, the resulting residue was acidified by adding 1 N HCl under ice-cooling and extracted with ethyl acetate. The extract was washed with water and saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated under a reduced pressure. By recrystallizing the resulting residue from acetonitrile, 200 mg (yield: 90%) of the title compound was obtained.

Provenance & Evidence