Dicyclohexylcarbodiimide → 5,5-Dimethyl-8-(1-pentyl)-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

HRID 126810Notes

Reaction equation

HRID 126810 reaction equation
[CH3:1][C:2]1([CH3:22])[C:17]2=[CH:18][CH:19]=[N:20][CH:21]=[C:16]2[C:5]2[C:6]([OH:15])=[CH:7][C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[CH:9][C:4]=2[O:3]1.[ClH:23].[N:24]1([CH2:30][CH2:31][CH2:32][C:33](O)=[O:34])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:23].[CH3:22][C:2]1([CH3:1])[C:17]2=[CH:18][CH:19]=[N:20][CH:21]=[C:16]2[C:5]2[C:6]([O:15][C:33](=[O:34])[CH2:32][CH2:31][CH2:30][N:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)=[CH:7][C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[CH:9][C:4]=2[O:3]1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 131720814-(Piperidin-1-yl)butanoic acid hydrochlorideHCID 202878825,5-dimethyl-10-hydroxy-8-(1-pentyl)-5H-[1]benzopyrano[3,4-d]pyridine

Product 1

HCID 202879025,5-Dimethyl-8-(1-pentyl)-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

Procedure

5,5-Dimethyl-8-(1-pentyl)-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride is prepared according to the method of Example 29 by reacting equimolar quantities of 5,5-dimethyl-10-hydroxy-8-(1-pentyl)-5H-[1]benzopyrano[3,4-d]pyridine and γ-piperidinobutyric acid hydrochloride in the presence of dicyclohexylcarbodiimide.

Sources & evidence

ORD record
ord-3ea38090948f45a8940b6a4b1b455ff4
Source dataset
uspto-grants-1981_03
Patent number
US04254116

Reaction notes

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