Dicyclohexylcarbodiimide → 5,5-Dimethyl-8-(1-cyclohexylethyl)-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

HRID 126812Notes

Reaction equation

HRID 126812 reaction equation
[CH3:1][C:2]1([CH3:25])[C:20]2=[CH:21][CH:22]=[N:23][CH:24]=[C:19]2[C:5]2[C:6]([OH:18])=[CH:7][C:8]([CH:10]([CH:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[CH3:11])=[CH:9][C:4]=2[O:3]1.[ClH:26].[N:27]1([CH2:33][CH2:34][CH2:35][C:36](O)=[O:37])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:26].[CH3:25][C:2]1([CH3:1])[C:20]2=[CH:21][CH:22]=[N:23][CH:24]=[C:19]2[C:5]2[C:6]([O:18][C:36](=[O:37])[CH2:35][CH2:34][CH2:33][N:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)=[CH:7][C:8]([CH:10]([CH:12]3[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]3)[CH3:11])=[CH:9][C:4]=2[O:3]1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 131720814-(Piperidin-1-yl)butanoic acid hydrochlorideHCID 202878495,5-dimethyl-10-hydroxy-8-(1-cyclohexylethyl)-5H[1]benzopyrano[3,4-d]pyridine

Product 1

HCID 202878785,5-Dimethyl-8-(1-cyclohexylethyl)-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

Procedure

5,5-Dimethyl-8-(1-cyclohexylethyl)-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride is prepared according to the method of Example 29 by reacting equimolar quantities of 5,5-dimethyl-10-hydroxy-8-(1-cyclohexylethyl)-5H[1]benzopyrano[3,4-d]pyridine and γ-piperidinobutyric acid hydrochloride in the presence of dicyclohexyl carbodiimide.

Sources & evidence

ORD record
ord-74edec1759e14e76bb281d0ec78b4c6e
Source dataset
uspto-grants-1981_03
Patent number
US04254116

Reaction notes

Loading…