Dicyclohexylcarbodiimide → 5,5-Dimethyl-8-(3-cyclopropyl-2-propyl)-10-[4-(piperidino)-butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

HRID 126813Notes

Reaction equation

HRID 126813 reaction equation
[CH3:1][C:2]1([CH3:23])[C:18]2=[CH:19][CH:20]=[N:21][CH:22]=[C:17]2[C:5]2[C:6]([OH:16])=[CH:7][C:8]([CH:10]([CH2:12][CH:13]3[CH2:15][CH2:14]3)[CH3:11])=[CH:9][C:4]=2[O:3]1.[ClH:24].[N:25]1([CH2:31][CH2:32][CH2:33][C:34](O)=[O:35])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:24].[CH3:23][C:2]1([CH3:1])[C:18]2=[CH:19][CH:20]=[N:21][CH:22]=[C:17]2[C:5]2[C:6]([O:16][C:34](=[O:35])[CH2:33][CH2:32][CH2:31][N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:7][C:8]([CH:10]([CH2:12][CH:13]3[CH2:14][CH2:15]3)[CH3:11])=[CH:9][C:4]=2[O:3]1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 131720814-(Piperidin-1-yl)butanoic acid hydrochlorideHCID 202878695,5-dimethyl-10-hydroxy-8-(3-cyclopropyl-2-propyl)-5H-[1]benzopyrano[3,4-d]pyridine

Product 1

HCID 202878735,5-Dimethyl-8-(3-cyclopropyl-2-propyl)-10-[4-(piperidino)-butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

Procedure

5,5-Dimethyl-8-(3-cyclopropyl-2-propyl)-10-[4-(piperidino)-butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride is prepared according to the method of Example 29 by reacting equimolar quantities of 5,5-dimethyl-10-hydroxy-8-(3-cyclopropyl-2-propyl)-5H-[1]benzopyrano[3,4-d]pyridine and γ-piperidinobutyric acid hydrochloride in the presence of dicyclohexyl-carbodiimide.

Sources & evidence

ORD record
ord-ac8fb6e79bba4843bf3a6be226cdbde6
Source dataset
uspto-grants-1981_03
Patent number
US04254116

Reaction notes

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