Dicyclohexylcarbodiimide → 5,5-Dimethyl-8-(2-tetradecyl)-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

HRID 126814Notes

Reaction equation

HRID 126814 reaction equation
[CH3:1][C:2]1([CH3:31])[C:26]2=[CH:27][CH:28]=[N:29][CH:30]=[C:25]2[C:5]2[C:6]([OH:24])=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:11])=[CH:9][C:4]=2[O:3]1.[ClH:32].[N:33]1([CH2:39][CH2:40][CH2:41][C:42](O)=[O:43])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:32].[CH3:31][C:2]1([CH3:1])[C:26]2=[CH:27][CH:28]=[N:29][CH:30]=[C:25]2[C:5]2[C:6]([O:24][C:42](=[O:43])[CH2:41][CH2:40][CH2:39][N:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]3)=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:11])=[CH:9][C:4]=2[O:3]1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 131720814-(Piperidin-1-yl)butanoic acid hydrochlorideHCID 202878565,5-dimethyl-10-hydroxy-8-(2-tetradecyl)-5H-[1]benzopyrano[3,4-d]pyridine

Product 1

HCID 202878415,5-Dimethyl-8-(2-tetradecyl)-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride

Procedure

5,5-Dimethyl-8-(2-tetradecyl)-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride is prepared according to the method of Example 29 by reacting equimolar quantities of 5,5-dimethyl-10-hydroxy-8-(2-tetradecyl)-5H-[1]benzopyrano[3,4-d]pyridine and γ-piperidinobutyric acid hydrochloride in the presence of dicyclohexyl carbodiimide.

Sources & evidence

ORD record
ord-48fd39d6697d483aabe55198fbfcfc37
Source dataset
uspto-grants-1981_03
Patent number
US04254116

Reaction notes

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