反应详情

温度

70 °C

To a solution of 3-cyanobenzaldehyde (4.5 g) in toluene (200 ml) was added (triphenylphosphoranylidene)acetaldehyde (13.6 g) and the mixture was stirred at 70° C. for 4 hours. The reaction mixture was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using dichloromethane as an eluant and then the product was recrystallized from a mixture of toluene and hexane to give the desired compound (3.09 g, yield 57%) as pale yellow needle crystals.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customThe residue was purified by chromatography on a silica gel column
3. customthe product was recrystallized from a mixture of toluene and hexane