HCID 18542728, compound → HCID 18542622, compound

Participants

Reaction Steps

To a suspension of [3-(3-cyanophenyl)-2-(E)-propenyl]ethyl carbonate (1.04 g) and N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)phenyl]ethanesulfonamide (1.15 g) in tetrahydrofuran (9 ml) were added tris(dibenzylideneacetone)palladium chloroform complex (0.077 g) and triphenylphosphine (0.039 g) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using dichloromethane/ethyl acetate=8/1 as an eluant to give the desired compound (1.57 g, yield quantitative) as a pale yellow oil.

Provenance & Evidence