Triphenylphosphine → HCID 20581790, compound

Participants

Reaction Steps

To a suspension of [3-(3-cyanophenyl)-2-methyl-2-(E)-propenyl]ethyl carbonate (1.10 g) and N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)phenyl]ethanesulfonamide (1.15 g) in tetrahydrofuran (9 ml) were added tris(dibenzylideneacetone)palladium chloroform complex (78 mg) and triphenylphosphine (39 mg) and the mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using dichloromethane/ethyl acetate=12/1 as an eluant to give the desired compound (0.58 g, yield 36%) as a colorless amorphous solid.

Provenance & Evidence