Tert-butyl 4-(3-methyl-4-nitrophenoxy)piperidine-1-carboxylate → Tert-butyl 4-(3-methyl-4-aminophenoxy)piperidine-1-carboxylate

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Reaction Steps

To a solution of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-2-methylnitrobenzene (3.23 g) in methanol (30 ml) was added palladium on carbon (0.21 g) and the mixture was stirred under a hydrogen atmosphere at room temperature for 4 hours. The reaction mixture was filtered and the filtrate concentrated in vacuo. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=1/1 as an eluant to give the desired compound (3.02 g, yield 99%) as a pale red oil.

Provenance & Evidence