Dicyclohexylcarbodiimide → HCID 20287834, compound

HRID 126819Notes

Reaction equation

HRID 126819 reaction equation
[CH3:1][C:2]1([CH3:28])[C:23]2=[CH:24][CH:25]=[N:26][CH:27]=[C:22]2[C:5]2[C:6]([OH:21])=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH3:11])=[CH:9][C:4]=2[O:3]1.[ClH:29].[N:30]1([CH2:36][CH2:37][CH2:38][C:39](O)=[O:40])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:29].[CH3:28][C:2]1([CH3:1])[C:23]2=[CH:24][CH:25]=[N:26][CH:27]=[C:22]2[C:5]2[C:6]([O:21][C:39](=[O:40])[CH2:38][CH2:37][CH2:36][N:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH3:11])=[CH:9][C:4]=2[O:3]1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 131720814-(Piperidin-1-yl)butanoic acid hydrochlorideHCID 20287894HCID 20287894, compound

Product 1

HCID 20287834HCID 20287834, compound

Procedure

5,5-Dimethyl-8-[5-phenyl-2-pentyl]-10-[4-(piperidino)butyryloxy]-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride is prepared according to the method of Example 29 by reacting equimolar quantities of 5,5-dimethyl-10-hydroxy-8-[5-phenyl-2-pentyl]-5H-[1]benzopyrano[3,4-d]pyridine and γ-piperidinobutyric acid hydrochloride in the presence of dicyclohexyl carbodiimide.

Sources & evidence

ORD record
ord-60abe926f7b64c96b7302dee9caa53c3
Source dataset
uspto-grants-1981_03
Patent number
US04254116

Reaction notes

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