HCID 22181096, compound → HCID 22181136, compound

Participants

Reaction Steps

To a solution of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-carbamoylnitrobenzene (5.7 g) in methanol (80 ml) was added palladium on carbon (0.6 g) and the mixture was stirred under a hydrogen atmosphere at room temperature for 2.5 hours. The reaction mixture was filtered. The filtrate was purified by chromatography on a silica gel column using dichloromethane/methanol=19/1 as an eluant to give the desired compound (4.8 g, yield 91%) as a pale yellow amorphous solid.

Provenance & Evidence