HCID 18542698, compound → HCID 18542675, compound

Participants

Reaction Steps

To a solution of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-(N-methylcarbamoyl)nitrobenzene (3.5 g) in methanol (50 ml) was added palladium on carbon (0.4 g) and the mixture was stirred under a hydrogen atmosphere at room temperature for 1 hour. The reaction mixture was filtered. The filtrate was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using dichloromethane/methanol=19/1 as an eluant to give the desired compound (2.9 g, yield 92%) as a yellow amorphous solid.

Provenance & Evidence