HCID 18542638, compound → HCID 18542605, compound

Participants

Reaction Steps

To a solution of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-(N,N-dimethylcarbamoyl)nitrobenzene (3.1 g) in methanol (30 ml) was added palladium on carbon (0.3 g) and the mixture was stirred under a hydrogen atmosphere at room temperature for 1 hour. The reaction mixture was filtered. The filtrate was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using dichloromethane/methanol 19/1 as an eluant to give the desired compound (2.8 g, yield 99%) as a yellow amorphous solid.

Provenance & Evidence