Triphenylphosphine → HCID 18542737, compound

Participants

Reaction Steps

To a solution of 1-t-butoxycarbonyl-4-hydroxypiperidine (6.3 9), methyl 3-chloro-5-nitrosalicylate (2.4 g) and triphenylphosphine (10.8 g) in dichloromethane (100 ml) was added diethyl azodicarboxylate (6.6 ml) and the mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=4/1 as an eluant to give the desired compound (3.4 g, yield 79%) as a pink solid.

Provenance & Evidence