Triphenylphosphine → HCID 18542735, compound

Participants

Reaction Steps

To a solution of 1-t-butoxycarbonyl-4-hydroxypiperidine (5.4 g), methyl 4-methyl-5-nitrosalicylate (2.8 g) and triphenylphosphine (9.0 g) in dichloromethane (100 ml) was added diethyl azodicarboxylate (5.4 ml) and the mixture was stirred at room temperature for 9 hours. The reaction mixture was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=4/1 as an eluant to give the desired compound (4.9 g, yield 93%) as a yellow oil.

Provenance & Evidence