HCID 18542602, compound → HCID 18542782, compound

HRID 1268235Notes

Reaction equation

HRID 1268235 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[C:20]([C:21](=[O:23])[NH2:22])=[CH:19][C:18]([N+:24]([O-])=O)=[C:17]([CH3:27])[CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[C:20]([C:21](=[O:23])[NH2:22])=[CH:19][C:18]([NH2:24])=[C:17]([CH3:27])[CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 18542602HCID 18542602, compound

Product 1

HCID 18542782HCID 18542782, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-5-carbamoyl-2-methylnitrobenzene (4.7 g) in methanol (120 ml) was added palladium on carbon (0.5 g) and the mixture was stirred under a hydrogen atmosphere at room temperature for 2 hours. The reaction mixture was filtered. The filtrate was concentrated in vacuo to give the desired compound (4.0 g, yield 93%) as a yellow amorphous solid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-83d459a76585423ebb7bb73918fdef91
Source dataset
uspto-grants-2003_04
Patent number
US06555556B1

Reaction notes

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