Sodium Hydroxide → HCID 69800487, compound

HRID 1268257Notes

Reaction equation

HRID 1268257 reaction equation
C([O:3][C:4](=[O:30])[C@@H:5]([O:27][CH2:28][CH3:29])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH:15]=[CH:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>C(O)C>[CH2:28]([O:27][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH:15]=[CH:16][C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)=[CH:11][CH:12]=1)[C:4]([OH:30])=[O:3])[CH3:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69800548HCID 69800548, compound

Product 1

HCID 69800487HCID 69800487, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(S)-2-Ethoxy-3-[4-(3-quinolin-2-yl-allyloxy)-phenyl]-propionic acid ethyl ester (example 41) (150 mg, 0.37 mmol) was dissolved in ethanol (2 mL) and sodium hydroxide (1N, 2.0 mL, 2.0 mmol) added. The mixture was stirred at room temperature for 16 h. The reaction mixture was concentrated in vacuo, added 2-propanol (2 mL) and diethyl ether (2 mL). The title compound was isolated by filtration.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additionadded 2-propanol (2 mL) and diethyl ether (2 mL)

Sources & evidence

ORD record
ord-6d99d0c9608f4dc085ea9db7c982f896
Source dataset
uspto-grants-2003_04
Patent number
US06555577B1

Reaction notes

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