2,3-Dichlorobenzeneboronic acid → (E)-Ethyl 3-(2',3'-dichloro-biphenyl-4-yl)-but-2-enoate

HRID 1268271Notes

Reaction equation

HRID 1268271 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1B(O)O.Br[C:13]1[CH:18]=[CH:17][C:16](/[C:19](/[CH3:26])=[CH:20]/[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:15][CH:14]=1>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][C:16](/[C:19](/[CH3:26])=[CH:20]/[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 27346612,3-Dichlorobenzeneboronic acidHCID 15933615(E)-ethyl 3-(4-bromophenyl)-but-2-enoate

Product 1

HCID 22557696(E)-Ethyl 3-(2',3'-dichloro-biphenyl-4-yl)-but-2-enoateYield 73%

Procedure

(E)-Ethyl 3-(2′,3′-Dichloro-biphenyl-4-yl)-but-2-enoate (1.07 g, 73% yield) was prepared from 2,3-dichlorophenylboronic acid (1.26 g, 6.60 mmol) and (E)-ethyl 3-(4-bromophenyl)-but-2-enoate (1.0 g, 4.40 mmol) by a procedure analogous to that described in example 52a.

Sources & evidence

ORD record
ord-f1fd00080b88413ea8db914ac0044f6f
Source dataset
uspto-grants-2003_04
Patent number
US06555577B1

Reaction notes

Loading…